As a psychiatric mental health nurse practitioner, it is essential for you to have a strong background in foundational neuroscience. In order to diagnose and treat clients, you must not only understand the pathophysiology of psychiatric disorders, but also how medications for these disorders impact the central nervous system. These concepts of foundational neuroscience can be challenging to understand. Therefore, this Discussion is designed to encourage you to think through these concepts, develop a rationale for your thinking, and deepen your understanding by interacting with your colleagues. Learning Objectives Students will: Analyze the agonist-to-antagonist spectrum of action of psychopharmacologic agents Compare the actions of g couple proteins to ion gated channels Analyze the role of epigenetics in pharmacologic action Analyze the impact of foundational neuroscience on the prescription of medications Learning Resources Note: To access this week’s required library resources, please click on the link to the Course Readings List, found in the Course Materials section of your Syllabus. Required Readings Note: All Stahl resources can be accessed through the Walden Library using this link. This link will take you to a log-in page for the Walden Library. Once you log into the library, the Stahl website will appear. Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York, NY: Cambridge University Press *Preface, pp. ix–x Note: To access the following chapters, click on the Essential Psychopharmacology, 4th ed tab on the Stahl Online website and select the appropriate chapter. Be sure to read all sections on the left navigation bar for each chapter. Chapter 1, “Chemical Neurotransmission” Chapter 2, “Transporters, Receptors, and Enzymes as Targets of Psychopharmacologic Drug Action” Chapter 3, “Ion Channels as Targets of Psychopharmacologic Drug Action” Document: Midterm Exam Study Guide (PDF) Document: Final Exam Study Guide (PDF) Required Media Laureate Education (Producer). (2016i). Introduction to psychopharmacology [Video file]. Baltimore, MD: Author. Note: The approximate length of this media piece is 3 minutes. Accessible player Optional Resources Laureate Education (Producer). (2009). Pathopharmacology: Disorders of the nervous system: Exploring the human brain [Video file]. Baltimore, MD: Author. Note: The approximate length of this media piece is 15 minutes. Dr. Myslinski reviews the structure and function of the human brain. Using human brains, he examines and illustrates the development of the brain and areas impacted by disorders associated with the brain. Accessible player Laureate Education (Producer). (2012). Introduction to advanced pharmacology [Video file]. Baltimore, MD: Author. Note: The approximate length of this media piece is 8 minutes. In this media presentation, Dr. Terry Buttaro, associate professor of practice at Simmons School of Nursing and Health Sciences, discusses the importance of pharmacology for the advanced practice nurse.